Research Associate I/II, Assay Development

Research Associate I/II, Assay Development

We are seeking a detail oriented and highly motivated Research Associate to join the assay development team in Bioanalytical Sciences at Amunix Pharmaceuticals.

The successful candidate will be responsible for performing immunochemistry techniques including ELISAs, MSD assays, Luminex, and anti-drug antibody assays, as well as preparing samples for mass spec analysis (LC-MS).

The Bioanalytical RA will assist in developing immunoassays to support multiple projects and will analyze pre-clinical study samples for drug concentration, biomarkers, and anti-drug antibodies.

This list contains the major duties and requirements of the job and is not all-inclusive.

Incumbent(s) may perform role-related duties other than those contained in this document.

ESSENTIAL FUNCTIONS

• Perform pre-clinical sample analysis using relevant assays (ELISA, MSD, anti-drug antibody, Luminex, etc.).

  Prepare samples for mass spec analysis.

• Assist in developing and qualifying complex assays for measuring the plasma concentration of XTENylated molecules and metabolites, and for detection and characterization of antibodies against XTENylated molecules.
• Prepare and characterize assay reagents using standard biochemical techniques such as protein conjugation, concentration determination, and UV/Vis spectrophotometry.
• Document all activities in an electronic notebook, compile data and analyze results in a timely fashion.
• Present data in group settings to update other teams on progress of assay development.
• Perform routine equipment maintenance, calibrations, and verifications as needed.
• Collaborate with other assay development team members to complete tasks and meet departmental goals.
• Work cross-functionally with members of other departments to complete tasks when required.

QUALIFICATIONS

• A minimum of a Bachelor’s degree in a scientific discipline with 1+ years of work experience or a Master’s degree in a related scientific discipline.
• Experience running or developing immunoassays (ELISA, MSD) or other immunochemistry techniques (i.e.

  Westerns, Luminex, etc.) is desirable.

• Experience with cell based assays or flow cytometry is desirable.
• Previous work in a GCP/GLP/GMP environment is a plus but not required
• Ability to work in a fast-paced, dynamic environment with effective time-management skills.
• Self-motivated to carry out both new and routine tasks.
• Must be willing to work as part of a team and demonstrate good interpersonal skills.
• Proficient working with Microsoft Word, Excel, and PowerPoint.
• Past experience with electronic notebook systems and GraphPad Prism a plus.

ABOUT AMUNIX

Amunix is leveraging our expertise in precision protein engineering to enable the promise of T cell engagers in solid tumors.

Our goal is to save cancer patients’ lives through the development and commercialization of breakthrough therapies that harness the immune system.

We have invented XTEN, a validated therapeutic half-life extension technology.

Our current focus is Pro-XTEN, a next-generation protease activated pro-drug platform, which enables selective activation of potent cancer therapies in the tumor microenvironment.

This overcomes a common challenge facing potent immune system activators: on-target, off-tumor toxicity.

Amunix’s two lead programs employ the Pro-XTEN technology to enhance the safety profile of T cell engagers.

XPATs (XTENylated Protease-Activated T Cell Engagers) have the potential to make off-the-shelf therapies redirecting T cells to solid tumors a reality.

Amunix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, or genetics.

In addition to federal law requirements, Amunix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training.

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