Research Scientist, Integrated Pharmacology

American College of Clinical Pharmacology

• Research Scientist, Integrated Pharmacology

Research Scientist, Integrated Pharmacology

Description

Job Description

We are seeking a highly independent, collaborative and innovative scientist to join the Quantitative Cellular Pharmacology team in the Integrated Pharmacology group at Vertex Pharmaceuticals.

The ideal candidate will be self-motivated with a strong foundation in cell biology and/or biochemistry and have experience with cell-based/biochemical assays.

The successful candidate will be responsible for developing human disease-relevant assays to understand and address the underlying cause of serious life-threatening diseases.

Target identification/validation, mechanism of action studies, and understanding drug candidate pharmacology using innovative approaches and technologies will be required.

Knowledge of multiplex assay platforms, data analysis, and data reporting is necessary.

The understanding of robust statistical analysis, multi-parametric data analysis and basic command line programming is a plus.

Preference will be given to candidates with a track record of innovation in the field.

The Integrated Pharmacology group supports late-stage drug discovery for all disease areas in the Vertex drug discovery portfolio at the Boston site and the Senior Scientist will be a member of multiple discovery project teams.

Key Responsibilities:

• Lead the development of cell-based and/or biochemical assays for small molecule discovery as a key member of discovery project teams
• Execute cell based and/or biochemical assays supporting medicinal chemistry optimization, characterize our lead molecules in in vitro / in vivo models of human disease and meet deliverables for preclinical development projects
• Analyze, critically interpret and present data to cross-functional project teams, and recommend courses of action based on datasets and discussions with biologists and chemists
• Propose and develop innovative approaches to small molecule discovery based on the latest technologies and publications in the field
• Interface closely with project teams to ensure assays are aligned with scientific project goals
• Identify and evaluate new technologies to improve efficiency and processes
• Strong interpersonal, verbal and written communication skills
• Be a key member of the Integrated Pharmacology group and serve as a strong representative on interdisciplinary project teams
• Responsible for internal documentation and reports required for regulatory documents
• Ensure data integrity and compliance under Vertex policies

Minimal Requirements :

• PhD (or equivalent degree) in a relevant discipline (Cell Biology, Molecular Biology, Pharmacology, Biochemistry or related Biological Sciences) and 0-5 years of productive, relevant industry or postdoctoral experience in cell-based and/or biochemical assays to lead discovery, optimization and characterization
• Strong understanding of Cell Biology and expertise in cell-based and/or biochemical assay development
• Self-motivation, independence, organization, effective communication and presentation skills; adept in solving/troubleshooting complex problems as well as the ability to navigate a fast-paced work environment
• A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law.

Vertex is an E-Verify Employer in the United States.

Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.

Job Information

• Job ID: 59786396
• Position Title: Research Scientist, Integrated Pharmacology

At Vertex, we bring together the brightest minds in the relentless pursuit of creating transformative medicines for people with serious and life-threatening diseases.

Founded in 1989 in Cambridge, Massachusetts, we are one of only a handful of biotechnology companies founded since 1976 that has discovered and developed four or more approved medicines in our own labs.

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